Rabbit Polyclonal Antibody to CLK1

包装: 1G|100G|500G|1KG|100KG

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别名:CDC like kinase 1; CLK; CLK1; Dual specificity protein kinase CLK1; EC 2.7.1.112
应用:WB,ICC
反应种属:Human,Mouse
规格：50μl/100μl

Description
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.Johnson K.W., J. Biol. Chem. 266:3402-3407(1991).Hanes J.J., J. Mol. Biol. 244:665-672(1994).Olsen J.V., Cell 127:635-648(2006).

Description

Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.Johnson K.W., J. Biol. Chem. 266:3402-3407(1991).Hanes J.J., J. Mol. Biol. 244:665-672(1994).Olsen J.V., Cell 127:635-648(2006).

Specification
Aliases	CDC like kinase 1; CLK; CLK1; Dual specificity protein kinase CLK1; EC 2.7.1.112
Entrez GeneID	1195;
Swissprot	P49759
WB Predicted band size	57kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Synthesized peptide derived from internal of human CLK1.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.