Rabbit Polyclonal Antibody to CNOT2 (Ab-101)

包装: 1G|100G|500G|1KG|100KG

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别名:CCR4-associated factor 2; CCR4-NOT transcription complex subunit 2; CCR4-NOT transcription complex; subunit 2; CDC36
应用:WB
反应种属:Human
规格：50μl/100μl

Description
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specificly involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES) cell identity.Albert T.K., Nucleic Acids Res. 28:809-817(2000).Zhang Q.-H., Genome Res. 10:1546-1560(2000).Ota T., Nat. Genet. 36:40-45(2004).

Description

Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specificly involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES) cell identity.Albert T.K., Nucleic Acids Res. 28:809-817(2000).Zhang Q.-H., Genome Res. 10:1546-1560(2000).Ota T., Nat. Genet. 36:40-45(2004).

Specification
Aliases	CCR4-associated factor 2; CCR4-NOT transcription complex subunit 2; CCR4-NOT transcription complex; subunit 2; CDC36
Entrez GeneID	4848;
Swissprot	Q9NZN8
WB Predicted band size	46kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized non-phosphopeptide derived from human CNOT2 around the phosphorylation site of serine 101 (S-L-S(p)-Q-G).
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.