Rabbit Polyclonal Antibody to CNOT7

包装: 1G|100G|500G|1KG|100KG

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别名:BTG1 binding factor 1; BTG1-binding factor 1; CCR4-NOT transcription complex; 7; CCR4-associated factor 1
应用:WB
反应种属:Human,Mouse
规格：50μl/100μl

Description
Has 3′-5′ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.Bogdan J.A., Biochem. J. 336:471-481(1998).The MGC Project Team; Genome Res. 14:2121-2127(2004).

Description

Has 3′-5′ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.Bogdan J.A., Biochem. J. 336:471-481(1998).The MGC Project Team; Genome Res. 14:2121-2127(2004).

Specification
Aliases	BTG1 binding factor 1; BTG1-binding factor 1; CCR4-NOT transcription complex; 7; CCR4-associated factor 1
Entrez GeneID	29883;
Swissprot	Q9UIV1
WB Predicted band size	36kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Synthesized peptide derived from N-terminal of human CNOT7.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.