Rabbit Polyclonal Antibody to COCH

包装: 1G|100G|500G|1KG|100KG

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别名:Cochlin, COCH-5B2, COCH, COCH5B2
应用:WB
反应种属:Human
规格：50μl/100μl

Description
The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94% and 79% amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated. [provided by RefSeq].

Description

The protein encoded by this gene is highly conserved in
human, mouse, and chicken, showing 94% and 79% amino acid identity
of human to mouse and chicken sequences, respectively.
Hybridization to this gene was detected in spindle-shaped cells
located along nerve fibers between the auditory ganglion and
sensory epithelium. These cells accompany neurites at the habenula
perforata, the opening through which neurites extend to innervate
hair cells. This and the pattern of expression of this gene in
chicken inner ear paralleled the histologic findings of acidophilic
deposits, consistent with mucopolysaccharide ground substance, in
temporal bones from DFNA9 (autosomal dominant nonsyndromic
sensorineural deafness 9) patients. Mutations that cause DFNA9 have
been reported in this gene. Alternative splicing results in
multiple transcript variants encoding the same protein. Additional
splice variants encoding distinct isoforms have been described but
their biological validities have not been demonstrated. [provided
by RefSeq].

Specification
Aliases	Cochlin, COCH-5B2, COCH, COCH5B2
Entrez GeneID	1690
Swissprot	O43405
WB Predicted band size	59.5kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This COCH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 492-520 amino acids from the C-terminal region of human COCH.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.