Rabbit Polyclonal Antibody to COL1A2 (N-term)

包装: 1G|100G|500G|1KG|100KG

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别名:Collagen alpha-2(I) chain, Alpha-2 type I collagen, COL1A2
应用:WB
反应种属:Human
规格：50μl/100μl

Description
This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish].

Description

This gene encodes the pro-alpha2 chain of type I collagen
whose triple helix comprises two alpha1 chains and one alpha2
chain. Type I is a fibril-forming collagen found in most connective
tissues and is abundant in bone, cornea, dermis and tendon.
Mutations in this gene are associated with osteogenesis imperfecta
types I-IV, Ehlers-Danlos syndrome type VIIB, recessive
Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and
atypical Marfan syndrome. Symptoms associated with mutations in
this gene, however, tend to be less severe than mutations in the
gene for the alpha1 chain of type I collagen (COL1A1) reflecting
the different role of alpha2 chains in matrix integrity. Three
transcripts, resulting from the use of alternate polyadenylation
signals, have been identified for this gene. [provided by R.
Dalgleish].

Specification
Aliases	Collagen alpha-2(I) chain, Alpha-2 type I collagen, COL1A2
Entrez GeneID	1278
Swissprot	P08123
WB Predicted band size	129.3kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This COL1A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-43 amino acids from the N-terminal region of human COL1A2.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.