Rabbit Polyclonal Antibody to COPS7A

包装: 1G|100G|500G|1KG|100KG

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别名:COP9 signalosome complex subunit 7a, SGN7a, Signalosome subunit 7a, Dermal papilla-derived protein 10, JAB1-containing signalosome subunit 7a, COPS7A, CSN7A, DERP10
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Description

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Specification
Aliases	COP9 signalosome complex subunit 7a, SGN7a, Signalosome subunit 7a, Dermal papilla-derived protein 10, JAB1-containing signalosome subunit 7a, COPS7A, CSN7A, DERP10
Entrez GeneID	50813
Swissprot	Q9UBW8
WB Predicted band size	30.3kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This COPS7A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 237-266 amino acids from the C-terminal region of human COPS7A.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500

	COPS7A Antibody (C-term) (Cat. #P31167) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the COPS7A antibody detected the COPS7A protein (arrow).
	COPS7A Antibody (C-term) (Cat. #P31167)immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of COPS7A Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.