Rabbit Polyclonal Antibody to COPZ1

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别名:CGI-120; coatomer protein complex; subunit zeta 1; COPZ; zeta1-COP
应用:WB,IHC
反应种属:Human,Mouse
规格：50μl/100μl

Description
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors By similarity.The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.Futatsumori M., J. Biochem. 128:793-801(2000).Lai C.-H., Genome Res. 10:703-713(2000).Zhang Q.-H., Genome Res. 10:1546-1560(2000)

Description

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors By similarity.The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.Futatsumori M., J. Biochem. 128:793-801(2000).Lai C.-H., Genome Res. 10:703-713(2000).Zhang Q.-H., Genome Res. 10:1546-1560(2000)

Specification
Aliases	CGI-120; coatomer protein complex; subunit zeta 1; COPZ; zeta1-COP
Entrez GeneID	22818;
Swissprot	P61923
WB Predicted band size	20kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Synthesized peptide derived from internal of human COPZ1.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100

	Western blot analysis of extracts from Jurkat cells and COS cells, using COPZ1 antibody P42364.
	Immunohistochemistry analysis of paraffin-embedded human cervix carcinoma tissue using COPZ1 antibody P42364.