Rabbit Polyclonal Antibody to CREB (Ab-129/133)

包装: 1G|100G|500G|1KG|100KG

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别名:cAMP responsive element binding protein 1; cAMP-response element binding protein; CREB-1; CREB1;
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.Xing J, et al. (1998) Mol Cell Biol 18(4): 1946-55.Tan Y, et al.( 1996) EMBO J; 15(17): 4629-42.Hao, M. et al. (1996) J. Biol. Chem. 271, 29380-29385.Mayo LD, et al. (2001) Biol Chem; 276(27): 25184-9.Lu, H. et al. (1997) Mol. Cell. Biol. 17, 5923-59

Description

Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.Xing J, et al. (1998) Mol Cell Biol 18(4): 1946-55.Tan Y, et al.( 1996) EMBO J; 15(17): 4629-42.Hao, M. et al. (1996) J. Biol. Chem. 271, 29380-29385.Mayo LD, et al. (2001) Biol Chem; 276(27): 25184-9.Lu, H. et al. (1997) Mol. Cell. Biol. 17, 5923-59

Specification
Aliases	cAMP responsive element binding protein 1; cAMP-response element binding protein; CREB-1; CREB1;
Entrez GeneID	1385;
Swissprot	P16220
WB Predicted band size	43kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized non-phosphopeptide derived from human CREB around the phosphorylation site of serine 129 or serine 133(S-R-R-P-S).
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100

	Western blot analysis of extracts from HeLa cells, treated with UV, using CREB (Ab-133) antibody P41689.
	Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using CREB (Ab-133) antibody P41689.