Rabbit Polyclonal Antibody to CREB-BP

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别名:CREB-binding protein; CBP CBP/MOZ FUSION GENE;
应用:WB,IHC,ICC
反应种属:Human
规格：50μl/100μl

Description
Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers.Zoi Lygerou, Nucleic Acids Res., Feb 1994; 22: 5332 – 5340.Karsten Grote, J. Biol. Chem., Dec 2004; 279: 55675 – 55681.Kumi Nagamoto-Combs, J. Biol. Chem., Feb 1997; 272: 6051.Stephen J. Elliman, Isaac, J. Biol. Chem., Jan 2006; 281: 16 -19

Description

Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers.Zoi Lygerou, Nucleic Acids Res., Feb 1994; 22: 5332 – 5340.Karsten Grote, J. Biol. Chem., Dec 2004; 279: 55675 – 55681.Kumi Nagamoto-Combs, J. Biol. Chem., Feb 1997; 272: 6051.Stephen J. Elliman, Isaac, J. Biol. Chem., Jan 2006; 281: 16 -19

Specification
Aliases	CREB-binding protein; CBP CBP/MOZ FUSION GENE;
Entrez GeneID	1387;
Swissprot	Q92793
WB Predicted band size	265kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized peptide derived from human CREB-BP.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100
ICC	1/100-1/500

	Western blot analysis of extracts from HeLa cells, treated with insulin (0.01U/ml, 15mins), using CREB-BP antibody P41793.
	Immunofluorescence analysis of A549 cells, using CREB-BP antibody P41793.
	Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using CREB-BP antibody P41793.