Rabbit Polyclonal Antibody to CSFR (Phospho-Tyr561)

包装: 1G|100G|500G|1KG|100KG

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别名:CD115; CSF-1-R; CSFMR; FMS; M-CSFR
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Hampe A., Oncogene Res. 4:9-17(1989)Andre C., Genomics 39:216-226(1997)Liu T., J. Proteome Res. 4:2070-2080(2005)

Description

Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Hampe A., Oncogene Res. 4:9-17(1989)Andre C., Genomics 39:216-226(1997)Liu T., J. Proteome Res. 4:2070-2080(2005)

Specification
Aliases	CD115; CSF-1-R; CSFMR; FMS; M-CSFR
Entrez GeneID	1436;
Swissprot	P07333
WB Predicted band size	130kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Peptide sequence around phosphorylation site of tyrosine 561 (N-S-Y(p)-T-F) derived from Human CSFR .
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/1000
IHC	1/50-1/100

	Western blot analysis of extracts from HepG2 cells treated with PMA using CSFR (Phospho-Tyr561) Antibody P40399.The lane on the right is treated with the antigen-specific peptide.
	Immunohistochemical analysis of paraffin-embedded human brain, using CSFR (Phospho-Tyr561) antibody P40399 (left)or the same antibody preincubated with blocking peptide (right).