Rabbit Polyclonal Antibody to CSK

包装: 1G|100G|500G|1KG|100KG

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别名:Tyrosine-protein kinase CSK; EC 2.7.10.2; C-SRC kinase; Protein-tyrosine kinase CYL; CSK
应用:WB,ICC
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.Partanen J., Oncogene 6:2013-2018(1991).Braeuninger A., Proc. Natl. Acad. Sci. U.S.A. 88:10411-10415(1991).Brauninger A., Gene 110:205-211(1992).

Description

Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.Partanen J., Oncogene 6:2013-2018(1991).Braeuninger A., Proc. Natl. Acad. Sci. U.S.A. 88:10411-10415(1991).Brauninger A., Gene 110:205-211(1992).

Specification
Aliases	Tyrosine-protein kinase CSK; EC 2.7.10.2; C-SRC kinase; Protein-tyrosine kinase CYL; CSK
Entrez GeneID	1445;
Swissprot	P41240
WB Predicted band size	55kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from internal of human CSK.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.