Rabbit Polyclonal Antibody to CSTA

包装: 1G|100G|500G|1KG|100KG

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别名:Cystatin-A, Cystatin-AS, Stefin-A, Cystatin-A, N-terminally processed, CSTA, STF1, STFA
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer.

Description

The cystatin superfamily encompasses proteins that contain
multiple cystatin-like sequences. Some of the members are active
cysteine protease inhibitors, while others have lost or perhaps
never acquired this inhibitory activity. There are three inhibitory
families in the superfamily, including the type 1 cystatins
(stefins), type 2 cystatins, and kininogens. This gene encodes a
stefin that functions as a cysteine protease inhibitor, forming
tight complexes with papain and the cathepsins B, H, and L. The
protein is one of the precursor proteins of cornified cell envelope
in keratinocytes and plays a role in epidermal development and
maintenance. Stefins have been proposed as prognostic and
diagnostic tools for cancer.

Specification
Aliases	Cystatin-A, Cystatin-AS, Stefin-A, Cystatin-A, N-terminally processed, CSTA, STF1, STFA
Entrez GeneID	1475
Swissprot	P01040
WB Predicted band size	11.0kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This CSTA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69-98 amino acids from the C-terminal region of human CSTA.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500

	CSTA Antibody (C-term) (Cat. #P31452) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the CSTA antibody detected the CSTA protein (arrow).
	Western blot analysis of CSTA (arrow) using rabbit polyclonal CSTA Antibody (C-term) (Cat. #P31452). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CSTA gene.
	CSTA Antibody (C-term) (P31452)immunohistochemistry analysis in formalin fixed and paraffin embedded human skin tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CSTA Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.