Rabbit Polyclonal Antibody to CtBP1 (Phospho-Ser422)

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别名:CTBP; C-terminal binding protein 1; EC 1.1.1;
应用:WB,IHC
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants.Schaeper U., Proc. Natl. Acad. Sci. U.S.A. 92:10467-10471(1995)Sewalt R.G.A.B., Mol. Cell. Biol. 19:777-787(1999)The MGC Project Team, Genome Res. 14:2121-2127(2004)

Description

This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants.Schaeper U., Proc. Natl. Acad. Sci. U.S.A. 92:10467-10471(1995)Sewalt R.G.A.B., Mol. Cell. Biol. 19:777-787(1999)The MGC Project Team, Genome Res. 14:2121-2127(2004)

Specification
Aliases	CTBP; C-terminal binding protein 1; EC 1.1.1;
Entrez GeneID	1487;
Swissprot	Q13363
WB Predicted band size	48kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around phosphorylation site of Serine 422(A-P-S(p)-P-G) derived from Human CtBP1.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/1000
IHC	1/50-1/100

	Western blot analysis of extracts from Jurkat cells treated with TNF using CtBP1 (Phospho-Ser422) Antibody P40496.The lane on the right is treated with the antigen-specific peptide.
	Immunohistochemical analysis of paraffin-embedded human brain tissue, using CtBP1 (Phospho-Ser422) antibody P40496 (left)or the same antibody preincubated with blocking peptide (right).