Rabbit Polyclonal Antibody to CTDSP1

包装: 1G|100G|500G|1KG|100KG

现货支持定制

QQ咨询
| 微信咨询

满200元免运费
正品保障提供发票
现货闪电当时发货

别名:Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1; EC 3.1.3.16; Nuclear LIM interactor-interacting factor 3; NLI-interacting factor 3; NLI-IF
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
Preferentially catalyzes the dephosphorylation of ‘Ser-5’ within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.Marquet S., Mamm. Genome 11:755-762(2000).Yeo M., J. Biol. Chem. 278:26078-26085(2003).Hillier L.W., Nature 434:724-731(2005)

Description

Preferentially catalyzes the dephosphorylation of ‘Ser-5’ within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.Marquet S., Mamm. Genome 11:755-762(2000).Yeo M., J. Biol. Chem. 278:26078-26085(2003).Hillier L.W., Nature 434:724-731(2005)

Specification
Aliases	Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1; EC 3.1.3.16; Nuclear LIM interactor-interacting factor 3; NLI-interacting factor 3; NLI-IF
Entrez GeneID	58190;
Swissprot	Q9GZU7
WB Predicted band size	30kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized peptide derived from N-terminal of human CTDSP1.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100

	Western blot analysis of extracts from HUVEC cells and HeLa cells, using CTDSP1 antibody P42334.
	Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using CTDSP1 antibody P42334.