Rabbit Polyclonal Antibody to CTNND2

包装: 1G|100G|500G|1KG|100KG

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别名:Catenin delta-2, Delta-catenin, GT24, Neural plakophilin-related ARM-repeat protein, NPRAP, Neurojungin, CTNND2, NPRAP
应用:WB,IHC
反应种属:Human, Mouse
规格：50μl/100μl

Description
This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome.

Description

This gene encodes an adhesive junction associated protein
of the armadillo/beta-catenin superfamily and is implicated in
brain and eye development and cancer formation. The protein encoded
by this gene promotes the disruption of E-cadherin based adherens
junction to favor cell spreading upon stimulation by hepatocyte
growth factor. This gene is overexpressed in prostate
adenocarcinomas and is associated with decreased expression of
tumor suppressor E-cadherin in this tissue. This gene resides in a
region of the short arm of chromosome 5 that is deleted in Cri du
Chat syndrome.

Specification
Aliases	Catenin delta-2, Delta-catenin, GT24, Neural plakophilin-related ARM-repeat protein, NPRAP, Neurojungin, CTNND2, NPRAP
Entrez GeneID	1501
Swissprot	Q9UQB3
WB Predicted band size	132.7kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse
Immunogen	This CTNND2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1131-1159 amino acids from the C-terminal region of human CTNND2.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500

	CTNND2 Antibody (C-term) (Cat. #P31104) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the CTNND2 antibody detected the CTNND2 protein (arrow).
	CTNND2 Antibody (C-term) (Cat. #P31104) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the CTNND2 antibody detected the CTNND2 protein (arrow).
	CTNND2 Antibody (C-term) (Cat. #P31104)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CTNND2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.