Rabbit Polyclonal Antibody to CXCR4(N-term)

包装: 1G|100G|500G|1KG|100KG

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别名:C-X-C chemokine receptor type 4, CXC-R4, CXCR-4, FB22, Fusin, HM89, LCR1, Leukocyte-derived seven transmembrane domain receptor, LESTR, Lipopolysaccharide-associated protein 3, LAP-3, LPS-associated protein 3, NPYRL, Stromal cell-derived factor 1 receptor, SDF-1 receptor, CD184, CXCR4
应用:WB
反应种属:Human, Mouse, Rat
规格：50μl/100μl

Description
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq].

Description

This gene encodes a CXC chemokine receptor specific for
stromal cell-derived factor-1. The protein has 7 transmembrane
regions and is located on the cell surface. It acts with the CD4
protein to support HIV entry into cells and is also highly
expressed in breast cancer cells. Mutations in this gene have been
associated with WHIM (warts, hypogammaglobulinemia, infections, and
myelokathexis) syndrome. Alternate transcriptional splice variants,
encoding different isoforms, have been characterized. [provided by
RefSeq].

Specification
Aliases	C-X-C chemokine receptor type 4, CXC-R4, CXCR-4, FB22, Fusin, HM89, LCR1, Leukocyte-derived seven transmembrane domain receptor, LESTR, Lipopolysaccharide-associated protein 3, LAP-3, LPS-associated protein 3, NPYRL, Stromal cell-derived factor 1 receptor, SDF-1 receptor, CD184, CXCR4
Entrez GeneID	7852
Swissprot	P61073
WB Predicted band size	39.7kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse, Rat
Immunogen	This CXCR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-79 amino acids from the N-terminal region of human CXCR4.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000-1/2000

All lanes: Anti-CXCR4 Antibody (N-term) at 1:2000 dilution + NCI-H460 whole cell lysate

Lysates/proteins at 20 µg per lane.
Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated (ASP1615) at 1/15000 dilution.

Observed band size: 50KDa

Blocking/Dilution buffer: 5% NFDM/TBST.

CXCR4 Antibody (N-term) (Cat. #P35098) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the CXCR4 antibody detected the CXCR4 protein (arrow).