Rabbit Polyclonal Antibody to Cyclin C (Phospho-Ser275)

包装: 1G|100G|500G|1KG|100KG

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别名:CG1C; cyclin C; SRB11;
应用:WB,IHC
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene.Lew D.J., Cell 66:1197-1206(1991)Li H., Genomics 32:253-259(1996)Mungall A.J., Nature 425:805-811(2003)

Description

The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene.Lew D.J., Cell 66:1197-1206(1991)Li H., Genomics 32:253-259(1996)Mungall A.J., Nature 425:805-811(2003)

Specification
Aliases	CG1C; cyclin C; SRB11;
Entrez GeneID	892;
Swissprot	P24863
WB Predicted band size	37kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around phosphorylation site of Serine 275(N-G-S(p)-A-N) derived from Human Cyclin C.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/1000
IHC	1/50-1/100

	Western blot analysis of extracts from 3T3 cells (Lane 2), A549 cells (Lane 3) and Hela cells (Lane 4), using Cyclin C (Phospho-Ser275) Antibody P40497. The lane on the left is treated with antigen-specific peptide.
	Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Cyclin C (Phospho-Ser275) antibody P40497 (left)or the same antibody preincubated with blocking peptide (right).