Rabbit Polyclonal Antibody to Cyclin-L1

包装: 1G|100G|500G|1KG|100KG

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别名:Cyclin-L; CCNL1;
应用:WB,IHC
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21.A. Hamid Boulares, J. Biol. Chem., Aug 1999; 274: 22932. Alessandra Pagano, Am J Physiol Lung Cell Mol Physiol, Jun 2007; 10.1152.Mi Young Kim, Genes & Dev., Sep 2005; 19: 1951 – 1967. Silke S篓鹿sse, Nucleic Acids Res., Feb 2004; 32: 669 – 680.

Description

Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21.A. Hamid Boulares, J. Biol. Chem., Aug 1999; 274: 22932. Alessandra Pagano, Am J Physiol Lung Cell Mol Physiol, Jun 2007; 10.1152.Mi Young Kim, Genes & Dev., Sep 2005; 19: 1951 – 1967. Silke S篓鹿sse, Nucleic Acids Res., Feb 2004; 32: 669 – 680.

Specification
Aliases	Cyclin-L; CCNL1;
Entrez GeneID	57018;
Swissprot	Q9UK58
WB Predicted band size	60kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human Cyclin-L1.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100

	Western blot analysis of extracts from HepG2 cells, using Cyclin-L1 antibody P41827.
	Western blot analysis of extracts from HeLa cells (Lane 2), A549 cells (Lane 3) and HepG2 cells (Lane 4), using Cyclin-L1 antiobdy P41827. The lane on the left is treated with systhesized peptide.
	Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Cyclin-L1 antibody P41827.