中文 
别名:Cytochrome P450 2C19, 11413-, (R)-limonene 6-monooxygenase, (S)-limonene 6-monooxygenase, (S)-limonene 7-monooxygenase, CYPIIC17, CYPIIC19, Cytochrome P450-11A, Cytochrome P450-254C, Mephenytoin 4-hydroxylase, CYP2C19应用:WB,IHC,FCM
反应种属:Human
规格：50μl/100μl
| Description |
|---|
| CYP2C19 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within its gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. |
| Specification | |
|---|---|
| Aliases | Cytochrome P450 2C19, 11413-, (R)-limonene 6-monooxygenase, (S)-limonene 6-monooxygenase, (S)-limonene 7-monooxygenase, CYPIIC17, CYPIIC19, Cytochrome P450-11A, Cytochrome P450-254C, Mephenytoin 4-hydroxylase, CYP2C19 |
| Entrez GeneID | 1557 |
| Swissprot | P33261 |
| WB Predicted band size | 55.9kDa |
| Host/Isotype | Rabbit IgG |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CYP2C19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-108 amino acids from the N-terminal region of human CYP2C19. |
| Formulation | Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Application | |
|---|---|
| WB | 1/1000 |
| IHC | 1/100-1/500 |
| FCM | 1/10-1/50 |
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Western blot analysis of CYP2C19 Antibody (N-term) (Cat. #P30444) in HL-60 cell line lysates (35ug/lane). CYP2C19 (arrow) was detected using the purified Pab. |
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Anti-CYP2C19 Antibody (N-term) at 1:1000 dilution + human liver lysate
Lysates/proteins at 20 μg per lane. Secondary Predicted band size : 56 kDa Blocking/Dilution buffer: 5% NFDM/TBST. |
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Confocal immunofluorescent analysis of CYP2C19 Antibody (N-term)(Cat#P30444) with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue). |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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