Rabbit Polyclonal Antibody to DAZ3

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别名:Deleted in azoospermia protein 3, DAZ3
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains one copy of the 10.8 kb repeat.

Description

This gene is a member of the DAZ gene family and is a
candidate for the human Y-chromosomal azoospermia factor (AZF). Its
expression is restricted to premeiotic germ cells, particularly in
spermatogonia. It encodes an RNA-binding protein that is important
for spermatogenesis. Four copies of this gene are found on
chromosome Y within palindromic duplications; one pair of genes is
part of the P2 palindrome and the second pair is part of the P1
palindrome. Each gene contains a 2.4 kb repeat including a 72-bp
exon, called the DAZ repeat; the number of DAZ repeats is variable
and there are several variations in the sequence of the DAZ repeat.
Each copy of the gene also contains a 10.8 kb region that may be
amplified; this region includes five exons that encode an RNA
recognition motif (RRM) domain. This gene contains one copy of the
10.8 kb repeat.

Specification
Aliases	Deleted in azoospermia protein 3, DAZ3
Entrez GeneID	57054
Swissprot	Q9NR90
WB Predicted band size	55.0kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This DAZ3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 445-474 amino acids from the C-terminal region of human DAZ3.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500

	DAZ3 Antibody (C-term) (Cat. #P31066) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the DAZ3 antibody detected the DAZ3 protein (arrow).
	DAZ3 Antibody (C-term) (Cat. #P31066)immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of DAZ3 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.