Rabbit Polyclonal Antibody to DCC

包装: 1G|100G|500G|1KG|100KG

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别名:colorectal cancer suppressor; deleted in colorectal carcinoma; netrin receptor DCC; tumor suppressor protein DCC;
应用:ICC
反应种属:Human
规格：50μl/100μl

Description
Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.Hedrick L., Genes Dev. 8:1174-1183(1994).Cho K.R., Genomics 19:525-531(1994).Sjoeblom T., Science 314:268-274(2006).

Description

Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.Hedrick L., Genes Dev. 8:1174-1183(1994).Cho K.R., Genomics 19:525-531(1994).Sjoeblom T., Science 314:268-274(2006).

Specification
Aliases	colorectal cancer suppressor; deleted in colorectal carcinoma; netrin receptor DCC; tumor suppressor protein DCC;
Entrez GeneID	1630;
Swissprot	P43146
WB Predicted band size	158kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized peptide derived from internal of human DCC.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.