Rabbit Polyclonal Antibody to DDR1 (Phospho-Tyr513)

包装: 1G|100G|500G|1KG|100KG

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别名:CAK; RTK6; TRKE; EDDR1;
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI).di Marco E., J. Biol. Chem. 268:24290-24295(1993)Johnson J.D., Proc. Natl. Acad. Sci. U.S.A. 90:5677-5681(1993)Laval S., Cell Growth Differ. 5:1173-1183(1994).

Description

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI).di Marco E., J. Biol. Chem. 268:24290-24295(1993)Johnson J.D., Proc. Natl. Acad. Sci. U.S.A. 90:5677-5681(1993)Laval S., Cell Growth Differ. 5:1173-1183(1994).

Specification
Aliases	CAK; RTK6; TRKE; EDDR1;
Entrez GeneID	780;
Swissprot	Q08345
WB Predicted band size	110kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Peptide sequence around phosphorylation site of tyrosine 513 (K-K-Y(p)-V-R) derived from Human DDR1 .
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/1000
IHC	1/50-1/100

	Western blot analysis of extracts from JK cells (Lane 2), using DDR1 (Phospho-Tyr513) Antibody P40471. The lane on the left is treated with antigen-specific peptide.
	Immunohistochemical analysis of paraffin-embedded human brain tissue using DDR1 (Phospho-Tyr513) antibody P40471 (left)or the same antibody preincubated with blocking peptide (right).