Rabbit Polyclonal Antibody to DHCR24

包装: 1G|100G|500G|1KG|100KG

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别名:DCE; SELADIN1; Nbla03646; seladin-1
应用:WB,IHC
反应种属:Human, Mouse, Rat
规格：50μl/100μl

Description
This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.

Description

This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.

Specification
Aliases	DCE; SELADIN1; Nbla03646; seladin-1
Swissprot	Q15392
WB Predicted band size	60 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse, Rat
Immunogen	Fusion protein of human DHCR24
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Application
WB	1/200-1/1000
IHC	1/30-1/150
ELISA	1/1000-1/2000

	Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Jurkat cells, HepG2 cells, Primary antibody: P08748(DHCR24 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
	The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P08748(DHCR24 Antibody) at dilution 1/40. (Original magnification: ×200)
	The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P08748(DHCR24 Antibody) at dilution 1/40. (Original magnification: ×200)