Rabbit Polyclonal Antibody to DMP1 (N-term)

包装: 1G|100G|500G|1KG|100KG

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别名:Dentin matrix acidic phosphoprotein 1, DMP-1, Dentin matrix protein 1, DMP1
应用:WB
反应种属:Human
规格：50μl/100μl

Description
Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene.

Description

Dentin matrix acidic phosphoprotein is an extracellular
matrix protein and a member of the small integrin binding ligand
N-linked glycoprotein family. This protein, which is critical for
proper mineralization of bone and dentin, is present in diverse
cells of bone and tooth tissues. The protein contains a large
number of acidic domains, multiple phosphorylation sites, a
functional arg-gly-asp cell attachment sequence, and a DNA binding
domain. In undifferentiated osteoblasts it is primarily a nuclear
protein that regulates the expression of osteoblast-specific genes.
During osteoblast maturation the protein becomes phosphorylated and
is exported to the extracellular matrix, where it orchestrates
mineralized matrix formation. Mutations in the gene are known to
cause autosomal recessive hypophosphatemia, a disease that
manifests as rickets and osteomalacia. The gene structure is
conserved in mammals. Two transcript variants encoding different
isoforms have been described for this gene.

Specification
Aliases	Dentin matrix acidic phosphoprotein 1, DMP-1, Dentin matrix protein 1, DMP1
Entrez GeneID	1758
Swissprot	Q13316
WB Predicted band size	55.8kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This DMP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 146-175 amino acids from the N-terminal region of human DMP1.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.