Rabbit Polyclonal Antibody to DNMT3L

包装: 1G|100G|500G|1KG|100KG

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别名:DNA (cytosine-5)-methyltransferase 3-like, DNMT3L
应用:WB
反应种属:Human
规格：50μl/100μl

Description
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases. This protein is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, this protein does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and it is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternative splicing results in two transcript variants. An additional splice variant has been described but its biological validity has not been determined.

Description

CpG methylation is an epigenetic modification that is
important for embryonic development, imprinting, and X-chromosome
inactivation. Studies in mice have demonstrated that DNA
methylation is required for mammalian development. This gene
encodes a nuclear protein with similarity to DNA
methyltransferases. This protein is not thought to function as a
DNA methyltransferase as it does not contain the amino acid
residues necessary for methyltransferase activity. However, this
protein does stimulate de novo methylation by DNA cytosine
methyltransferase 3 alpha and it is thought to be required for the
establishment of maternal genomic imprints. This protein also
mediates transcriptional repression through interaction with
histone deacetylase 1. Alternative splicing results in two
transcript variants. An additional splice variant has been
described but its biological validity has not been determined.

Specification
Aliases	DNA (cytosine-5)-methyltransferase 3-like, DNMT3L
Entrez GeneID	29947
Swissprot	Q9UJW3
WB Predicted band size	43.6kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This DNMT3L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 355-381 amino acids from the C-terminal region of human DNMT3L.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.