Rabbit Polyclonal Antibody to DOCK1

包装: 1G|100G|500G|1KG|100KG

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别名:180 kDa protein downstream of CRK; dedicator of cytokinesis protein 1; DOC1; DOCK180;
应用:WB
反应种属:Human
规格：50μl/100μl

Description
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1.Hasegawa H., Mol. Cell. Biol. 16:1770-1776(1996).Deloukas P., Nature 429:375-381(2004).Matsuda M., J. Biol. Chem. 271:14468-14472(1996).

Description

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1.Hasegawa H., Mol. Cell. Biol. 16:1770-1776(1996).Deloukas P., Nature 429:375-381(2004).Matsuda M., J. Biol. Chem. 271:14468-14472(1996).

Specification
Aliases	180 kDa protein downstream of CRK; dedicator of cytokinesis protein 1; DOC1; DOCK180;
Entrez GeneID	1793;
Swissprot	Q14185
WB Predicted band size	215kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized peptide derived from internal of human DOCK1.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.