中文 
别名:DLP1; DNM1L; Dnm1p/Vps1p-like protein; DRP1; DVLP应用:WB
反应种属:Human
规格：50μl/100μl
| Description |
|---|
| Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation. Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues. Also required for mitochondrial fission during mitosis. Required for formation of endocytic vesicles. Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L)which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles. Required for programmed necrosis execution. Isoform 1 and isoform 4 inhibit peroxisomal division when overexpressed.Shin H.-W., J. Biochem. 122:525-530(1997).Hong Y.-R., Biochem. Biophys. Res. Commun. 249:697-703(1998).Imoto M., J. Cell Sci. 111:1341-1349(1998). |
| Specification | |
|---|---|
| Aliases | DLP1; DNM1L; Dnm1p/Vps1p-like protein; DRP1; DVLP |
| Entrez GeneID | 10059; |
| Swissprot | O00429 |
| WB Predicted band size | 80kDa |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from C-terminal of human DNM1L. |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Application | |
|---|---|
| WB | 1/500-1/3000 |
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Western blot analysis of extracts from HuvEc cells (Lane 2), HepG2 cells (Lane 3), colo cells (Lane 4), 293 cells (Lane 5) and JK cells (Lane 6), using DRP1 (Ab-637) antiobdy P41786. The lane on the left is treated with synthesized peptide. |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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