Rabbit Polyclonal Antibody to DSG1

包装: 1G|100G|500G|1KG|100KG

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别名:Desmoglein-1, Cadherin family member 4, Desmosomal glycoprotein 1, DG1, DGI, Pemphigus foliaceus antigen, DSG1, CDHF4
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. The protein encoded by this gene has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus foliaceus.

Description

Desmosomes are cell-cell junctions between epithelial,
myocardial and certain other cell types. Desmoglein 1 is a
calcium-binding transmembrane glycoprotein component of desmosomes
in vertebrate epithelial cells. Currently, three desmoglein
subfamily members have been identified and all are members of the
cadherin cell adhesion molecule superfamily. These desmoglein gene
family members are located in a cluster on chromosome 18. The
protein encoded by this gene has been identified as the autoantigen
of the autoimmune skin blistering disease pemphigus foliaceus.

Specification
Aliases	Desmoglein-1, Cadherin family member 4, Desmosomal glycoprotein 1, DG1, DGI, Pemphigus foliaceus antigen, DSG1, CDHF4
Entrez GeneID	1828
Swissprot	Q02413
WB Predicted band size	113.7kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This DSG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 471-499 amino acids from the Central region of human DSG1.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500

	DSG1 Antibody (Center) (Cat. #P31467) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the DSG1 antibody detected the DSG1 protein (arrow).
	DSG1 Antibody (Center) (P31467)immunohistochemistry analysis in formalin fixed and paraffin embedded human skin tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of DSG1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.