中文 
别名:HVH1; MKP1; CL100; MKP-1; PTPN10应用:WB
反应种属:Human,Mouse
规格：50μl/100μl
| Description |
|---|
| The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. |
| Specification | |
|---|---|
| Aliases | HVH1; MKP1; CL100; MKP-1; PTPN10 |
| Entrez GeneID | 1843; |
| Swissprot | P28562 |
| WB Predicted band size | 39kDa |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthetic peptide corresponding to residues near the C terminal of human dual specificity phosphatase 1 |
| Formulation | Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol. |
| Application | |
|---|---|
| WB | 1/500-1/2000 |
 |
Gel: 10%SDS-PAGE Lysates (from left to right): Human fetal lung tissue Amount of lysate: 30ug per lane Primary antibody: 1/300 dilution Secondary antibody dilution: 1/8000 Exposure time: 30 seconds |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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