Rabbit Polyclonal Antibody to DUSP6

包装: 1G|100G|500G|1KG|100KG

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别名:dual specificity phosphatase 6, MKP3, PYST1
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.

Description

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.

Specification
Aliases	dual specificity phosphatase 6, MKP3, PYST1
Entrez GeneID	1848;
Swissprot	Q16828
WB Predicted band size	27kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Fusion protein corresponding to a region derived from 206-381 amino acids of human dual specificity phosphatase 6
Formulation	Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Application
WB	1/500-1/2000
IHC	1/25-1/100
ELISA	1:1000-1:5000

	Gel: 10%SDS-PAGELane1: Jurkat cell lysateLane2: Human fetal kidney tissue lysateLysates: 30ug per lanePrimary antibody: 1/450 dilutionSecondary antibody: Goat anti Rabbit IgG – H&L (HRP) at 1/10000 dilutionExposure time: 1 minute
	The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using 31069(DUSP6 Antibody) at dilution 1/25, on the right is treated with the fusion protein.