Rabbit Polyclonal Antibody to E2F4

包装: 1G|100G|500G|1KG|100KG

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别名:E2F-4; p107/p130-binding protein;
应用:WB,IHC
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5′-TTTC[CG]CGC-3′ found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1.Kathryn M. Kinross, Blood, Aug 2006; 108: 886 – 895.Dawei Wang, Mol. Cell. Biol., May 2000; 20: 3417 – 3424.Stephan P. Persengiev, Mol. Cell. Biol., Sep 1999; 19: 6048 – 6056.Stefan Gaubatz, Mol. Cell. Biol., Feb 2001; 21: 1384 – 1392.

Description

Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5′-TTTC[CG]CGC-3′ found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1.Kathryn M. Kinross, Blood, Aug 2006; 108: 886 – 895.Dawei Wang, Mol. Cell. Biol., May 2000; 20: 3417 – 3424.Stephan P. Persengiev, Mol. Cell. Biol., Sep 1999; 19: 6048 – 6056.Stefan Gaubatz, Mol. Cell. Biol., Feb 2001; 21: 1384 – 1392.

Specification
Aliases	E2F-4; p107/p130-binding protein;
Entrez GeneID	1874;
Swissprot	Q16254
WB Predicted band size	44kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human E2F4.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100

	Western blot analysis of extracts from COS7 cells, using E2F4 antibody P41798.
	Western blot analysis of extracts from JK cells (Lane 2), using E2F4 antiobdy P41798. The lane on the left is treated with synthesized peptide.
	Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using E2F4 antibody P41798.