Rabbit Polyclonal Antibody to EIF3D

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别名:eIF-3 zeta; eIF3 p66; eIF3d; EIF3S7; Eukaryotic translation initiation factor 3 subunit 7
应用:WB,IHC
反应种属:Human,Mouse
规格：50μl/100μl

Description
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. HAMAP-Rule MF_03003Asano K., J. Biol. Chem. 272:27042-27052(1997).Kalnine N., Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.Collins J.E., Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004).

Description

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. HAMAP-Rule MF_03003Asano K., J. Biol. Chem. 272:27042-27052(1997).Kalnine N., Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.Collins J.E., Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004).

Specification
Aliases	eIF-3 zeta; eIF3 p66; eIF3d; EIF3S7; Eukaryotic translation initiation factor 3 subunit 7
Entrez GeneID	8664;
Swissprot	O15371
WB Predicted band size	64kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Synthesized peptide derived from internal of human EIF3D.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100

	Western blot analysis of extracts from 3T3 cells, using EIF3D antibody P42404.
	Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using EIF3D antibody P42404.