Rabbit Polyclonal Antibody to ENSA

包装: 1G|100G|500G|1KG|100KG

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别名:Alpha-endosulfine, ARPP-19e, ENSA
应用:WB,FCM
反应种属:Human, Mouse
规格：50μl/100μl

Description
ENSA belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes.

Description

ENSA belongs to a highly
conserved cAMP-regulated phosphoprotein (ARPP) family. This protein
was identified as an endogenous ligand for the sulfonylurea
receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the
ATP-sensitive potassium (KATP) channel, which is located on the
plasma membrane of pancreatic beta cells and plays a key role in
the control of insulin release from pancreatic beta cells. This
protein is thought to be an endogenous regulator of KATP channels.
In vitro studies have demonstrated that this protein modulates
insulin secretion through the interaction with KATP channel, and
this gene has been proposed as a candidate gene for type 2
diabetes.

Specification
Aliases	Alpha-endosulfine, ARPP-19e, ENSA
Entrez GeneID	2029
Swissprot	O43768
WB Predicted band size	13.4kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse
Immunogen	This ENSA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-66 amino acids from the Central region of human ENSA.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
FCM	1/10-1/50

	ENSA Antibody (Center) (Cat. #P30787) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the ENSA antibody detected the ENSA protein (arrow).
	ENSA Antibody (Center) (Cat. #P30787) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the ENSA antibody detected the ENSA protein (arrow).
	ENSA Antibody (Center) (Cat. #P30787) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.