Rabbit Polyclonal Antibody to EPHA1

包装: 1G|100G|500G|1KG|100KG

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别名:EC 2.7.10.1; EPA1; EPH; EPHT; EPHT1
应用:WB,ICC
反应种属:Human
规格：50μl/100μl

Description
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.Hirai H., Science 238:1717-1720(1987).Owshalimpur D., Mol. Cell. Probes 13:169-173(1999).Hillier L.W., Nature 424:157-164(2003).

Description

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.Hirai H., Science 238:1717-1720(1987).Owshalimpur D., Mol. Cell. Probes 13:169-173(1999).Hillier L.W., Nature 424:157-164(2003).

Specification
Aliases	EC 2.7.10.1; EPA1; EPH; EPHT; EPHT1
Entrez GeneID	2041;
Swissprot	P21709
WB Predicted band size	108kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized peptide derived from internal of human EPHA1.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
ICC	1/100-1/500

	Western blot analysis of extracts from COLO205 cells, using EPHA1 antibody P41926.
	Immunofluorescence analysis of HeLa cells, using EPHA1 antibody P41926.