Rabbit Polyclonal Antibody to EPHA2/3/4 (Phospho-Tyr588/596)

包装: 1G|100G|500G|1KG|100KG

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别名:ECK; MPK-5; SEK2; kinase EphA2;
应用:WB,ICC
反应种属:Human,Mouse
规格：50μl/100μl

Description
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. Lindberg R.A., Mol. Cell. Biol. 10:6316-6324(1990)Zhang Y., Mol. Cell. Proteomics 4:1240-1250(2005)Zhuang G., J. Biol. Chem. 282:2683-2694(2007)

Description

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. Lindberg R.A., Mol. Cell. Biol. 10:6316-6324(1990)Zhang Y., Mol. Cell. Proteomics 4:1240-1250(2005)Zhuang G., J. Biol. Chem. 282:2683-2694(2007)

Specification
Aliases	ECK; MPK-5; SEK2; kinase EphA2;
Entrez GeneID	1969;
Swissprot	P29317
WB Predicted band size	130kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Peptide sequence around phosphorylation site of tyrosine 588/596 (K-T-Y(p)-V-R)/(R-T-Y(p)-V-D) derived from Human EPHA2/3/4.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/1000
ICC	1/100-1/200

	Western blot analysis of extracts from HepG2 cells using EPHA2/3/4 (Phospho-Tyr588/596) Antibody P40401.The lane on the right is treated with the antigen-specific peptide.
	Immunofluorescence staining of methanol-fixed HeLa cells using EPHA2/3/4 (Phospho-Tyr588/596) Antibody P40401.