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别名:ARCC2; ECK; EPHA2;应用:WB
反应种属:Human,Mouse
规格：50μl/100μl
| Description |
|---|
| Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway.Lindberg R.A., Mol. Cell. Biol. 10:6316-6324(1990)Gregory S.G., Nature 441:315-321(2006) |
| Specification | |
|---|---|
| Aliases | ARCC2; ECK; EPHA2; |
| Entrez GeneID | 1969; |
| Swissprot | P29317 |
| WB Predicted band size | 110kDa |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine 594 (H-T-Y(p)-E-D) derived from Human EPHA2/5. |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Application | |
|---|---|
| WB | 1/500-1/1000 |
 |
Western blot analysis of extracts from JK cells (Lane 2), using EPHA2/5 (Phospho-Tyr594) Antibody P40532. The lane on the left is treated with antigen-specific peptide. |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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