中文 
别名:EK8; hEK8; EPH-like kinase 8;应用:WB
反应种属:Human
规格：50μl/100μl
| Description |
|---|
| Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Rikova K., Cell 131:1190-1203(2007) [PubMed: 18083107]Richter M., J. Neurosci. 27:14205-14215(2007) [PubMed: 18094260]Fu W.Y., Nat. Neurosci. 10:67-76(2007) [PubMed: 17143272]. |
| Specification | |
|---|---|
| Aliases | EK8; hEK8; EPH-like kinase 8; |
| Entrez GeneID | 2043; |
| Swissprot | P54764 |
| WB Predicted band size | 110kDa |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine 596 (R-T-Y(p)-V-D) derived from Human EPHA4 . |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Application | |
|---|---|
| WB | 1/500-1/1000 |
 |
Western blot analysis of extracts from JK cells (Lane 2), using EPHA4 (Phospho-Tyr596) Antibody P40533. The lane on the left is treated with antigen-specific peptide. |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
暂无评论
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
发表回复