Rabbit Polyclonal Antibody to Epo-R (Ab-426)

包装: 1G|100G|500G|1KG|100KG

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别名:Erythropoietin receptor; EPO-R;
应用:WB
反应种属:Human
规格：50μl/100μl

Description
Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling.Winkelmann J.C., Blood 76:24-30(1990) [PubMed: 2163695].Jones S.S.,Blood 76:31-35(1990) [PubMed: 2163696].Noguchi C.T., Blood 78:2548-2556(1991) [PubMed: 1668606].

Description

Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling.Winkelmann J.C., Blood 76:24-30(1990) [PubMed: 2163695].Jones S.S.,Blood 76:31-35(1990) [PubMed: 2163696].Noguchi C.T., Blood 78:2548-2556(1991) [PubMed: 1668606].

Specification
Aliases	Erythropoietin receptor; EPO-R;
Entrez GeneID	2057;
Swissprot	P19235
WB Predicted band size	55kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized peptide derived from Internal of human Epo-R.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.