Rabbit Polyclonal Antibody to EPOR

包装: 1G|100G|500G|1KG|100KG

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别名:Erythropoietin receptor, EPO-R, EPOR
应用:WB,ICC,FCM
反应种属:Human
规格：50μl/100μl

Description
This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.

Description

This gene encodes the erythropoietin receptor which is a
member of the cytokine receptor family. Upon erythropoietin
binding, this receptor activates Jak2 tyrosine kinase which
activates different intracellular pathways including: Ras/MAP
kinase, phosphatidylinositol 3-kinase and STAT transcription
factors. The stimulated erythropoietin receptor appears to have a
role in erythroid cell survival. Defects in the erythropoietin
receptor may produce erythroleukemia and familial erythrocytosis.
Dysregulation of this gene may affect the growth of certain tumors.
Alternate splicing results in multiple transcript variants.

Specification
Aliases	Erythropoietin receptor, EPO-R, EPOR
Entrez GeneID	2057
Swissprot	P19235
WB Predicted band size	55.1kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This EPOR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 329-357 amino acids from the Central region of human EPOR.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
ICC	1/10-1/50
FCM	1/10-1/50

	EPOR Antibody (Center) (Cat. #P31676) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the EPOR antibody detected the EPOR protein (arrow).
	Confocal immunofluorescent analysis of EPOR Antibody (Center)(Cat#P31676) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).
	EPOR Antibody (Center) (Cat. #P31676) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.