中文 
别名:3′-5′ exoribonuclease 1; 3′-5′ exonuclease ERI1; Eri-1 homolog; Histone mRNA 3′-end-specific exoribonuclease; Histone mRNA 3′-exonuclease 1应用:WB
反应种属:Human
规格：50μl/100μl
| Description |
|---|
| RNA exonuclease that binds to the 3′-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2′ and 3′-hydroxyl groups at the last nucleotide of the histone 3′-end is required for efficient degradation of RNA substrates. Also able to degrade the 3′-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5′-ACCCA-3′ sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3′-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.Dominski Z., Mol. Cell 12:295-305(2003).Ota T., Nat. Genet. 36:40-45(2004).Bechtel S., BMC Genomics 8:399-399(2007) |
| Specification | |
|---|---|
| Aliases | 3′-5′ exoribonuclease 1; 3′-5′ exonuclease ERI1; Eri-1 homolog; Histone mRNA 3′-end-specific exoribonuclease; Histone mRNA 3′-exonuclease 1 |
| Entrez GeneID | 90459; |
| Swissprot | Q8IV48 |
| WB Predicted band size | 40kDa |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human ERI1. |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Application | |
|---|---|
| WB | 1/500-1/3000 |
 |
Western blot analysis of extracts from COLO205 cells, using ERI1 antibody P42738. |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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