Rabbit Polyclonal Antibody to ERVWE1

包装: 1G|100G|500G|1KG|100KG

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别名:Syncytin-1, Endogenous retrovirus group W member 1, Env-W, Envelope polyprotein gPr73, Enverin, HERV-7q Envelope protein, HERV-W envelope protein, HERV-W_7q212 provirus ancestral Env polyprotein, Syncytin, Surface protein, SU, gp50, Transmembrane protein, TM, gp24, ERVW-1, ERVWE1
应用:WB
反应种属:Human
规格：50μl/100μl

Description
Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene’s protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

Description

Many different human endogenous retrovirus (HERV) families
are expressed in normal placental tissue at high levels, suggesting
that HERVs are functionally important in reproduction. This gene is
part of an HERV provirus on chromosome 7 that has inactivating
mutations in the gag and pol genes. This gene is the envelope
glycoprotein gene which appears to have been selectively preserved.
The gene’s protein product is expressed in the placental
syncytiotrophoblast and is involved in fusion of the
cytotrophoblast cells to form the syncytial layer of the placenta.
The protein has the characteristics of a typical retroviral
envelope protein, including a furin cleavage site that separates
the surface (SU) and transmembrane (TM) proteins which form a
heterodimer. Alternatively spliced transcript variants encoding the
same protein have been found for this gene.

Specification
Aliases	Syncytin-1, Endogenous retrovirus group W member 1, Env-W, Envelope polyprotein gPr73, Enverin, HERV-7q Envelope protein, HERV-W envelope protein, HERV-W_7q212 provirus ancestral Env polyprotein, Syncytin, Surface protein, SU, gp50, Transmembrane protein, TM, gp24, ERVW-1, ERVWE1
Entrez GeneID	30816
Swissprot	Q9UQF0
WB Predicted band size	59.9kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This ERVWE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 493-521 amino acids from the C-terminal region of human ERVWE1.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.