Rabbit Polyclonal Antibody to EXOSC6 (N-term)

包装: 1G|100G|500G|1KG|100KG

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别名:Exosome complex component MTR3, Exosome component 6, mRNA transport regulator 3 homolog, hMtr3, p11, EXOSC6, MTR3
应用:WB
反应种属:Human
规格：50μl/100μl

Description
This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.

Description

This gene product constitutes one of the subunits of the
multisubunit particle called exosome, which mediates mRNA
degradation. The composition of human exosome is similar to its
yeast counterpart. This protein is homologous to the yeast Mtr3
protein. Its exact function is not known, however, it has been
shown using a cell-free RNA decay system that the exosome is
required for rapid degradation of unstable mRNAs containing AU-rich
elements (AREs), but not for poly(A) shortening. The exosome does
not recognize ARE-containing mRNAs on its own, but requires
ARE-binding proteins that could interact with the exosome and
recruit it to unstable mRNAs, thereby promoting their rapid
degradation.

Specification
Aliases	Exosome complex component MTR3, Exosome component 6, mRNA transport regulator 3 homolog, hMtr3, p11, EXOSC6, MTR3
Entrez GeneID	118460
Swissprot	Q5RKV6
WB Predicted band size	28.2kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This EXOSC6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-38 amino acids from the N-terminal region of human EXOSC6.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000

All lanes : Anti-EXOSC6 Antibody (N-term) at 1:1000 dilution
Lane 1: Jurkat whole cell lysate
Lane 2: WiDr whole cell lysate
Lane 3: Hela whole cell lysate
Lane 4: K562 whole cell lysate

Lysates/proteins at 20 µg per lane.

Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.

Predicted band size : 28 kDa

Blocking/Dilution buffer: 5% NFDM/TBST.

本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。

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