中文 
别名:DKFZp762A223; FA-D2; FA4; FACD; Fanconi anemia应用:WB
反应种属:Human
规格：50μl/100μl
| Description |
|---|
| Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching. Ho GP, Margossian S, Taniguchi T, D’Andrea AD (2006)Mol Cell Biol 26, 7005-15. Nakanishi K, et al. (2002)Nat Cell Biol 4, 913-20. Taniguchi T, et al. (2002) Cell 109, 459-72 . |
| Specification | |
|---|---|
| Aliases | DKFZp762A223; FA-D2; FA4; FACD; Fanconi anemia |
| Entrez GeneID | 2177; |
| Swissprot | Q9BXW9 |
| WB Predicted band size | 166kDa |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Peptide sequence around phosphorylation site of serine 222 (G-D-S(p)-Q-H) derived from Human FANCD2. |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Application | |
|---|---|
| WB | 1/500-1/1000 |
 |
Western blot analysis of extracts from HT29 cells treated with CalyculinA using Phospho-FANCD2 (Ser222) antibody P40599.The lane on the right is treated with the antigen-specific peptide. |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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