Rabbit Polyclonal Antibody to FGA (N-term)

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别名:Fibrinogen alpha chain, Fibrinopeptide A, Fibrinogen alpha chain, FGA
应用:WB,IHC,FCM
反应种属:Human
规格：50μl/100μl

Description
FGA is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types.

Description

FGA is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types.

Specification
Aliases	Fibrinogen alpha chain, Fibrinopeptide A, Fibrinogen alpha chain, FGA
Entrez GeneID	2243
Swissprot	P02671
WB Predicted band size	95.0kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This FGA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 116-144 amino acids from the N-terminal region of human FGA.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Application
WB	1/1000
IHC	1/100-1/500
FCM	1/10-1/50

	FGA Antibody (N-term) (Cat. #P30418) western blot analysis in human blood plasma tissue lysates (35ug/lane).This demonstrates the FGA antibody detected the FGA protein (arrow).
	Confocal immunofluorescent analysis of FGA Antibody (N-term)(Cat#P30418) with HepG2 cell followed by Alexa Fluor® 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
	FGA Antibody (N-term) (RB18707) IHC analysis in formalin fixed and paraffin embedded human breast carcinoma tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the FGA Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.