Rabbit Polyclonal Antibody to FGFR3

包装: 1G|100G|500G|1KG|100KG

现货支持定制

QQ咨询
| 微信咨询

满200元免运费
正品保障提供发票
现货闪电当时发货

别名:2.7.1.112; CEK2; HSFGFR3EX; fibroblast growth factor receptor 3 isoform 1 precursor; fibroblast growth factor receptor 3 isoform 2 precursor
应用:WB,IHC
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B. Secreted isoform 3 retains its capacity to bind FGF1 and FGF2 and hence may interfere with FGF signaling.Jing Chen, Blood, Jul 2005; 106: 328 – 337.Qing Zhang, Diabetes, Jan 2007; 56: 96 – 106.Nigel P. Pringle, Development, Jan 2003; 130: 93.Gladys Valverde-Franco, Hum. Mol. Genet., Feb 2004; 13: 271 – 284.

Description

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B. Secreted isoform 3 retains its capacity to bind FGF1 and FGF2 and hence may interfere with FGF signaling.Jing Chen, Blood, Jul 2005; 106: 328 – 337.Qing Zhang, Diabetes, Jan 2007; 56: 96 – 106.Nigel P. Pringle, Development, Jan 2003; 130: 93.Gladys Valverde-Franco, Hum. Mol. Genet., Feb 2004; 13: 271 – 284.

Specification
Aliases	2.7.1.112; CEK2; HSFGFR3EX; fibroblast growth factor receptor 3 isoform 1 precursor; fibroblast growth factor receptor 3 isoform 2 precursor
Entrez GeneID	2261;
Swissprot	P22607
WB Predicted band size	95kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human FGFR3.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100

	Western blot analysis of extracts from LOVO cells, using FGFR3 antibody P41799.
	Western blot analysis of extracts from 293 cells (Lane 2) and HepG2 cells (Lane 3), using FGFR3 antiobdy P41799. The lane on the left is treated with synthesized peptide.
	Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using FGFR3 antibody P41799.