Rabbit Polyclonal Antibody to FIR

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别名:FERM; RhoGEF and pleckstrin domain protein 2; FGD1-related Cdc42-GEF; FIR; FRG
应用:WB
反应种属:Human,Mouse
规格：50μl/100μl

Description
Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion By similarity.Nagase T., DNA Res. 5:31-39(1998).The MGC Project Team, Genome Res. 14:2121-2127(2004).Jandrig B., Oncogene 23:9295-9302(2004).

Description

Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion By similarity.Nagase T., DNA Res. 5:31-39(1998).The MGC Project Team, Genome Res. 14:2121-2127(2004).Jandrig B., Oncogene 23:9295-9302(2004).

Specification
Aliases	FERM; RhoGEF and pleckstrin domain protein 2; FGD1-related Cdc42-GEF; FIR; FRG
Entrez GeneID	9855;
Swissprot	O94887
WB Predicted band size	119kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Synthesized peptide derived from Internal of human FIR.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.