Rabbit Polyclonal Antibody to FRS2 (Ab-196)

包装: 1G|100G|500G|1KG|100KG

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别名:FGFR signalling adaptor; FGFR signalling adaptor SNT-1; SNT-1; SNT2; SUC1-associated neurotrophic factor target
应用:WB
反应种属:Human
规格：50μl/100μl

Description
Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.The MGC Project Team; Genome Res. 14:2121-2127(2004).Xu H., J. Biol. Chem. 273:17987-17990(1998).Meakin S.O., J. Biol. Chem. 274:9861-9870(1999).

Description

Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.The MGC Project Team; Genome Res. 14:2121-2127(2004).Xu H., J. Biol. Chem. 273:17987-17990(1998).Meakin S.O., J. Biol. Chem. 274:9861-9870(1999).

Specification
Aliases	FGFR signalling adaptor; FGFR signalling adaptor SNT-1; SNT-1; SNT2; SUC1-associated neurotrophic factor target
Entrez GeneID	10818;
Swissprot	Q8WU20
WB Predicted band size	65kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized non-phosphopeptide derived from human FRS2 around the phosphorylation site of tyrosine 196 (H-T-Y(p)-V-N).
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000

	Western blot analysis of extracts from HepG2 cells, using FRS2 (Ab-196) antibody P41730.
	Western blot analysis of extracts from 293 cells (Lane 2), using FRS2 (Ab-196) antiobdy P41730. The lane on the left is treated with synthesized peptide.