Rabbit Polyclonal Antibody to FZD6

包装: 1G|100G|500G|1KG|100KG

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别名:FZ6; FZ-6; HFZ6; NDNC10
应用:IHC
反应种属:Human, Mouse
规格：50μl/100μl

Description
This gene represents a member of the ‘frizzled’ gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.

Description

This gene represents a member of the ‘frizzled’ gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.

Specification
Aliases	FZ6; FZ-6; HFZ6; NDNC10
Swissprot	O60353
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse
Immunogen	Synthetic peptide of human FZD6
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Application
IHC	1/100-1/300
ELISA	1/2000-1/10000

	The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P04518(FZD6 Antibody) at dilution 1/60. (Original magnification: ×200)
	The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P04518(FZD6 Antibody) at dilution 1/60. (Original magnification: ×200)