Rabbit Polyclonal Antibody to FZR1

包装: 1G|100G|500G|1KG|100KG

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别名:FZR; CDH1; FZR2; HCDH; HCDH1; CDC20C
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C.

Description

Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C.

Specification
Aliases	FZR; CDH1; FZR2; HCDH; HCDH1; CDC20C
Entrez GeneID	51343;
Swissprot	Q9UM11
WB Predicted band size	55kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Fusion protein of human FZR1
Formulation	Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Application
WB	1/500-1/2000
IHC	1/25-1/100

	Gel: 8%SDS-PAGE Lysate: 40 μg Lane: Human placenta tissue Primary antibody: 1/400 dilution Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 3 minutes
	Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue using P43418 at dilution 1/20.
	Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue using P43418 at dilution 1/20.