Rabbit Polyclonal Antibody to Gab2 (Ab-623)

包装: 1G|100G|500G|1KG|100KG

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别名:GRB2-associated-binding protein 2; Growth factor receptor bound protein 2-associated protein 2; GRB2-associated binder 2; pp100; KIAA0571
应用:WB
反应种属:Human
规格：50μl/100μl

Description
Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.Nishida K., Blood 93:1809-1816(1999).Nagase T., DNA Res. 5:31-39(1998).Salomon A.R., Proc. Natl. Acad. Sci. U.S.A. 100:443-448(2003).

Description

Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.Nishida K., Blood 93:1809-1816(1999).Nagase T., DNA Res. 5:31-39(1998).Salomon A.R., Proc. Natl. Acad. Sci. U.S.A. 100:443-448(2003).

Specification
Aliases	GRB2-associated-binding protein 2; Growth factor receptor bound protein 2-associated protein 2; GRB2-associated binder 2; pp100; KIAA0571
Entrez GeneID	9846;
Swissprot	Q9UQC2
WB Predicted band size	74kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized non-phosphopeptide derived from human Gab2 around the phosphorylation site of serine 623 (P-S-S(p)-P-S).
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.